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Product Name: Felodipine
Catalog #: SIH-323-50MG
Size: 50mg
Type: Inhibitor
Description: L-type Ca channel blocker
Research Area: Ion Channels
CAS Number: 72509-76-3
Formula: C18H19Cl2NO4
Molecular weight: 384.25
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 100mM in ethanol and to 100mM in DMSO.
Appearance: Light Yellow Solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.

Safety Phrases: S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with shin and eyes

Risk Phrases: R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
R62 - Possible risk of impaired fertility

Hazard Phrases: H302
Datasheet: SIH 323 Felodipine Ion Channel Inhibitor
Price: $199.00 USD Add to Cart Bulk Quote

Structure of Felodipine

Research Background: Felodipine is an L-type Ca2+ channel blocker (1). In isolated rat ventricular myocytes, using a whole-cell patch-clamp technique, it displays a Ki of 11 nM (2). It is a clinically useful antihypertensive agent (3) which attenuates the hypertrophic effect of cyclosporine on transplanted hearts (4).
References: 1. Furakawa T., et al. (2005) J Cardiovasc. Pharmacol. 45(3): 241-246.
2. Zahradnikova Z., Minarovic I., Zahradnik I. (2007) J Pharmacol Exp. Ther. 322(2): 638-645.
3. Manzo B.A., Matalka M.S., Ravnan S.L. (2003) Pharmacotherapy. 23(11): 1508-1512.
4. Schwitter J., et al. (1999) J Heart Lung Transplant. 18(10): 1003-1013.

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