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Product Name: DMPO
Catalog #: SIH-324-125MG
Size: 125mg
Type: Inhibitor
Description: Nitrone adduct formation
Research Area: Oxidative Stress
CAS Number: 3317-61-1
Formula: C6H11NO
Molecular weight: 113.16
Source/Host: Synthetic
Purity: >99%
Solubility: Soluble to 100mM in ethanol and to 100mM in DMSO
Appearance: Colorless solid
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.

Safety Phrases: S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with shin and eyes
Datasheet: SIH 324 DMPO Oxidative Stress Inhibitor
Price: $129.00 USD Add to Cart Bulk Quote

Structure of DMPO

Research Background: The formation of free radicals and other highly reactive oxygen species has been implicated in the pathogenesis of many disease states (1). The ability to identify these species is crucial, and spin trapping has accomplished this goal. DMPO (5,5-dimethyl-1-pyrroline N-oxide) is one of the least toxic to cells and animals, and possesses convenient pharmacokinetics (uptake, distribution, metabolism and excretion) in biological systems (2-6). Recent studies have determined that nitric oxide may substantially affect the quantitative determination of DMPO adducts, and therefore extra caution is required when studying generation of these species in the presence of nitric oxide or its radicals (1). DMPO adducts can be generated with protein and DNA radicals (7).
References: 1. Reszka K.J., et al. (2006) Nitric Oxide 15: 133-141.
2. Ramirez D.C., Gomez-Mejiba S.E., and Mason R.P. (2007) Nat Protoc. 2(3): 512-522.
3. Khan N., et al. (2003) Free Radic. Biol. Med 34:1473–1481.
4. Haseloff R.F., et al. (1997) FEBS Lett 418:73–75.
5. Schaefer C.F., Janzen E.G., West M.S., Poyer J.L., and Kosanke S.D. (1996) Free Radic. Biol. Med 21:427–436.
6. Anzai K., et al. (2003) Arch. Biochem. Biophys 415:251–256.
7. Free Radic Biol Med. 2009 April 1; 46(7): 853–865. doi:10.1016/j.freeradbiomed.2008.12.020.
8. Chatterjee S., Ehrenshaft, M., Bhattacharjee ,S., Derterding, L.J., Bonini, M.G., Corbett, J., Kadiiska, M.B., Tomer K.B. and Mason, R.P. 2009 Free Radic. Med. and Biol. 46:454-461.

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