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Product Name: MG-132
Catalog #: SIH-326-5MG
Size: 5mg
Type: Inhibitor
Description: Proteasome Inhibitor
Research Area: Heat Shock
CAS Number: 133407-82-6
Formula: C26H41N3O5
Molecular weight: 475.6
Source/Host: Synthetic
Purity: >98%
Solubility: May be dissolved in 45mg/mL of DMSO, DMF or ethanol
Appearance: White powder
Storage Temp: -20°C
Shipping Temp: Blue Ice or 4°C
Safety Phrases: Classification: Caution: Substance not yet fully tested.

Safety Phrases: S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Datasheet: SIH 326 MG 132 Inhibitor
Price: $99.00 USD Add to Cart Bulk Quote

Structure of MG-132

Research Background: Specific inhibitor of the 20S proteasome (Ki=4 nM). Blocks NFKB activation by blocking IKB proteolysis (IC50=3 M). It stimulates autophagy, induces heat shock response and is cell permeable.
References: 1. Tsubuki S., et al. (1996) J. Biochem. 119:572.
2. Wu W.K., et al. (2010) Autophagy 6:228.
3. Meriin A.B., et al. (1998) J. Biol. Chem. 273:6373.

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