Pyr41

Name: Pyr41
SKU: SIH-330
Availability: InStock

E1 UAE inhibitor

Catalog No. SIH-330

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CAS No.	418805-02-4
Molecular Formula	C17H13N3O7

SKU: SIH-330 Categories: Inhibitor, Small Molecules

Product Name	Pyr41
Description	E1 UAE inhibitor
Purity	>98%
CAS No.	418805-02-4
Molecular Formula	C₁₇H₁₃N₃O₇
Molecular Weight	371.3
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	Soluble in 25 mg/ml DMSO
Source	Synthetic
Appearance	Brown Powder
SMILES	CCOC(=O)C1=CC=C(C=C1)N2C(=O)/C(=CC3=CC=C(O3)[N+](=O)[O-])/C(=O)N2
InChI	InChI=1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9-
InChIKey	ARGIPZKQJGFSGQ-LCYFTJDESA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H302 – May be harmful if swallowed H317 – May cause an allergic skin reaction Precautionary Statements: P280 – Wear protective gloves
Cite This Product	Pyr41 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-330)

Alternative Names	Ethyl 4-{(4Z)-4-[(5-nitro-2-furyl)methylene]-3,5-dioxo-1-pyrazolidinyl}benzoate, PYR-41, 4[4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester
Research Areas	Apoptosis, Cancer
PubChem ID	5335621
Scientific Background	Inhibits ubiquitin activating enzyme E1 (>60% inhibition at 10 µM) with little or no activity against E2 or E3. Cell permeable.
References	1. Yang Y., et al. (2007) Cancer Res. 67: 9472. 2. Mi L., et al. (2009) J. Biol. Chem. 284: 17039.

Chemical structure of Pyr41 (SIH-330), a E1 UAE inhibitor. CAS #: 418805-02-4. Molecular Formula: C17H13N3O7 . Molecular Weight: 371.3 g/mol.

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