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| Product Name | MLN4924 |
| Description |
NEDD8 activating enzyme inhibitor |
| Purity | >98% |
| CAS No. | 905579-51-3 |
| Molecular Formula | C21H25N5O4S |
| Molecular Weight | 443.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 10 mg/ml DMSO |
| Source | Synthetic |
| Appearance | White Powder |
| SMILES | C1CC2=CC=CC=C2[C@H]1NC3=C4C=CN(C4=NC=N3)[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N |
| InChI | InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-, |
| InChIKey | MPUQHZXIXSTTDU-QXGSTGNESA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | mlN4924 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-331) |
Biological Description
| Alternative Names | [(1S,2S,4R)-4-{4-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl]methyl sulfamate, Sulfamic acid |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 16720766 |
| Scientific Background | Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. It suppresses the growth of human tumor xenografts in mice. Cell permeable. |
| References |
1. Soucy T.A., et al. (2009) Nature. 458:732. 2. Milhollen M.A., et al. (2010) Blood. 116:1515. |
Product Images
Chemical structure of MLN4924 (SIH-331), a Nedd8 activating enzyme inhibitor. CAS #: 905579-51-3. Molecular Formula: C21H25N5O4S. Molecular Weight: 443.2 g/mol.
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