Aclacinomycin A

Proteasome inhibitor

Catalog No. SIH-335

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CAS No. 57576-44-0
Molecular Formula C42H53NO15
SKU: SIH-335 Categories: ,

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SIH-335_Aclacinomycin_A_Chemical_Structure.png
Product Name Aclacinomycin A
Description

Proteasome inhibitor

Purity >98%
CAS No. 57576-44-0
Molecular Formula C42H53NO15
Molecular Weight 811.9
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 30 mg/ml DMSO or DMF
Source Synthetic
Appearance Yellow-Orange Solid
SMILES CC[C@]1(C[C@@H](C2=C(C3=C(C=C2[C@H]1C(=O)OC)C(=O)C4=C(C3=O)C(=CC=C4)O)O)O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O[C@H]6C[C@@H]([C@@H]([C@@H](O6)C)O[C@H]7CCC(=O)[C@@H](O7)C)O)N(C)C)O
InChI InChI=1S/C42H53NO15/c1-8-42(51)17-28(33-22(35(42)41(50)52-7)14-23-34(38(33)49)37(48)32-21(36(23)47)10-9-11-26(32)45)56-30-15-24(43(5)6)39(19(3)54-30)58-31-16-27(46)40(20(4)55-31)57-29-13-12-25(44)18(
InChIKey USZYSDMBJDPRIF-SVEJIMAYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product Aclacinomycin A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-335)

Biological Description

Alternative Names Methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-4-O-{2,6-dideoxy-4-O-[(2R,6S)-6-methyl-5-oxotetrahydro-2H-pyran-2-yl]-?-L-lyxo-hexopyranosyl}-3-(dimethylamino)-?-L-lyx o-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydro-1-tetracenecarboxylate, Aclarubicin
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Proteasome Inhibitors
PubChem ID 451415
Scientific Background Specific inhibitor of the 20S proteasome chymotrypsin-like activity. Antitumor agent. Cell permeable.
References 1. Figueiroda-Pereira M.E., et al. (1996) J. Biol. Chem. 271:16455.

Product Images

<p>Chemical structure of Aclacinomycin A (SIH-335), a Proteasome inhibitor. CAS #: 57576-44-0. Molecular Formula: C42H53NO15. Molecular Weight: 811.9 g/mol.</p>

Chemical structure of Aclacinomycin A (SIH-335), a Proteasome inhibitor. CAS #: 57576-44-0. Molecular Formula: C42H53NO15. Molecular Weight: 811.9 g/mol.

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