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| Product Name | NSC-66811 |
| Description |
p53/mdm2 inhibitor |
| Purity | >98% |
| CAS No. | 6964-62-1 |
| Molecular Formula | C23H20N2O |
| Molecular Weight | 340.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 25 mg/ml DMSO |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | CC1=NC2=C(C=C1)C=CC(=C2O)C(C3=CC=CC=C3)NC4=CC=CC=C4 |
| InChI | InChI=1S/C23H20N2O/c1-16-12-13-18-14-15-20(23(26)22(18)24-16)21(17-8-4-2-5-9-17)25-19-10-6-3-7-11-19/h2-15,21,25-26H,1H3 |
| InChIKey | WEENRMPCSWFMTE-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | NSC-66811 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-338) |
Biological Description
| Alternative Names | 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol, 7-[Anilino(phenyl)methyl]-2-methylquinolin-8-ol |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, p53/mdm2 Inhibitors |
| PubChem ID | 248986 |
| Scientific Background | A novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. Binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable. |
| References | 1. Lu Y., et al. (2006) J. Med.Chem. 49: 3759. |
Product Images
Chemical structure of NSC-66811 (SIH-338), a p53/mdm2 inhibitor. CAS #: 6964-62-1. Molecular Formula: C23H20N2O. Molecular Weight: 340.4 g/mol.
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