Nutlin-3

p53/mdm2 inhibitor

Catalog No. SIH-344

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CAS No. 548472-68-0
Molecular Formula C30H30Cl2N4O4
SKU: SIH-344 Categories: ,

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SIH-344_Nutlin-3_Chemical_Structure.png
Product Name Nutlin-3
Description

p53/mdm2 inhibitor

Purity >98%
CAS No. 548472-68-0
Molecular Formula C30H30Cl2N4O4
Molecular Weight 581.9
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 100 mM DMSO and Ethanol
Source Synthetic
Appearance Yellow solid
SMILES CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)
InChIKey BDUHCSBCVGXTJM-UHFFFAOYSA-N
Safety Phrases Classification: Caution – Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product Nutlin-3 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-344)

Biological Description

Alternative Names (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5- dihydro-imidazole -1-carbonyl]-piperazin-2-one
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, p53/mdm2 Inhibitors
PubChem ID 216345
Scientific Background MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 µM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
References 1. Vassilev et al (2004) Science 303: 844.

Product Images

<p>Chemical structure of Nutlin-3 (SIH-344), a p53/mdm2 inhibitor. CAS #: 548472-68-0. Molecular Formula: C30H30Cl2N4O4. Molecular Weight: 581.9 g/mol.</p>

Chemical structure of Nutlin-3 (SIH-344), a p53/mdm2 inhibitor. CAS #: 548472-68-0. Molecular Formula: C30H30Cl2N4O4. Molecular Weight: 581.9 g/mol.

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