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| Product Name | Huperzine A |
| Description |
ACH inhibitor |
| Purity | >95% (HPLC); NMR (conforms) |
| CAS No. | 102518-79-6 |
| Molecular Formula | C15H18N2O |
| Molecular Weight | 242.32 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO, methanol or ethanol. |
| Source | Synthetic |
| Appearance | Off-White solid |
| SMILES | C/C=C/1[C@@H]2CC3=C([C@]1(CC(=C2)C)N)C=CC(=O)N3 |
| InChI | InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10?,15-/m1/s1 |
| InChIKey | ZRJBHWIHUMBLCN-JYXJEATCSA-N |
| Safety Phrases |
Classification: Toxic Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H301+ H311 +H331 – Toxic if swallowed, in contact with skin or inhaled H315 - Causes skin irritation. H319 - Causes serious eye irritation. H335 - May cause respiratory irritation. Precautionary Phrases: P261 - Avoid breathing dust/fume/gas/mist/vapours/spray. P280 - Wear protective gloves/protective clothing. P301+ P310 – IF SWALLOWED: Immediately call POISON CENTER or doctor/physician. P305+ P351+ P338 – IF IN EYES: rinse cautiously with water for several minutes. If wearing contact lenses remove them and continue to rinse. P311 – call a POISON CENTER or doctor/physician |
| Cite This Product | Huperzine A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-365) |
Biological Description
| Alternative Names | (1R,9S,13E)- 1-Amino- 13-ethylidene- 11-methyl- 6-azatricyclo[7.3.1.02,7] trideca- 2(7),3,10- trien- 5-one |
| Research Areas | Glutamate Receptors, Ion Channels, Neuroscience, Neurotransmitter Receptors, NMDA Receptors |
| PubChem ID | 44461111 |
| Scientific Background | Huperzine A is an acetylcholinesterase inhibitor. It is known for enhancing learning and memory by protecting a neurotransmitter molecule in the brain. Huperzine is also a NMDA glutamate receptor antagonist (1-2). The effects on the treatment of Alzheimer’s disease is under studies (1-3). Recent studies of Huperzine A highlight the potential therapeutic use for dementia by slowing down the neuronal cell death caused by glutamate (4). |
| References |
1. Bai Dl., Tang Xc., He YC., Curr MedChem. (2000) 7(3): 355-74. 2. Tang L., Wang r., Tang x., (2005) Acta Acta Pharmacologica 26(6): 673-678. 3. Ved Hs,. Koenig ml., Dave JR., Doctor BP.(1997) Neurorport. 8(4): 963-8. 4. Li WM., Kan KK., Carlier PR., Pang YP., Han YF. YF., (2007) Curr Alzheimer Res. 4: 386-396. |
Product Images
Chemical structure of Huperzine A (SIH-365), a ACH inhibitor. CAS #: 102518-79-6. Molecular Formula: C15H18N2O. Molecular Weight: 242.32 g/mol.
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