IOX1

Name: IOX1
SKU: SIH-377
Availability: InStock

JMJD inhibitor

Catalog No. SIH-377

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CAS No.	5852-78-8
Molecular Formula	C10H7NO3

SKU: SIH-377 Categories: Inhibitor, Small Molecules

Product Name	IOX1
Description	JMJD inhibitor
Purity	>98% (TLC); NMR (Conforms)
CAS No.	5852-78-8
Molecular Formula	C₁₀H₇NO₃
Molecular Weight	189.2
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Inhibitor
Solubility	May be dissolved in DMSO (20 mg/ml)
Source	Synthetic
Appearance	Yellow powder
SMILES	C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O
InChI	InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
InChIKey	JGRPKOGHYBAVMW-UHFFFAOYSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	IOX1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-377)

Alternative Names	8-Hydroxy-5-quinolinecarboxylic acid; (5-Carboxy-8HQ)
Research Areas	Cell Signaling
PubChem ID	459617
Scientific Background	IOX1 is a cell permeable inhibitor of the JMJD family of 2-oxoglutarate-dependent histone demethylases (IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 M for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively1). It is a broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling (1).
References	1. King O.N., et al. (2010) PLoS One. 5: e15535.

Chemical structure of IOX1 (SIH-377), a JMJD inhibitor. CAS #: 5852-78-8. Molecular Formula: C10H7 NO3. Molecular Weight: 189.2 g/mol.

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