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| Product Name | 3-Methyladenine |
| Description |
Autophagosome inhibitor |
| Purity | >98% |
| CAS No. | 5142-23-4 |
| Molecular Formula | C6H7N5 |
| Molecular Weight | 149.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (10 mg/ml) or 100% ethanol (5 mg/ml, warm). |
| Source | Synthetic |
| Appearance | White solid. |
| SMILES | C[N]2C1=NC=NC1=C(N=C2)N |
| InChI | InChI=1S/C6H7N5/c1-11-3-10-5(7)4-6(11)9-2-8-4/h2-3H,7H2,1H3 |
| InChIKey | FSASIHFSFGAIJM-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | 3-Methyladenine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-408) |
Biological Description
| Alternative Names | 3-MA, 3-Methyl-3H-purin-6-amine |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 1673 |
| Scientific Background | 3-Methyladenine inhibits phosphatidylinositol 3-kinase (PI3 kinase) and in doing so also is an inhibitor of autophagy by inhibiting autophagosome formation. |
| References |
1. Blommaart E.F., et al. (1997) Eur J Biochem. 243(1-2): 240-6. 2. Lin Y.C., et al. (2012) J Immunol. 189(8): 4154-64. 3. Wu Y.T., et al. (2010) J Biol Chem. 285(14): 10850-61. |
Product Images
Chemical structure of 3-Methyladenine (SIH-408), a Autophagosome inhibitor. CAS #: 5142-23-4. Molecular Formula: C6H7N5. Molecular Weight: 149.2 g/mol.
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