115-7C

Hsp70 Activator

Catalog No. SIH-123

5 out of 5 based on 1 customer rating
CAS No.
Molecular Forumla C23H22Cl2N2O5
5 out of 5 based on 1 customer rating
(1 customer review)

USD $120.00USD $450.00

SKU: SIH-123 Categories: , .

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SIH-123-115-7C-Chemical-Structure.png

Overview

Product Name 115-7C
Description

Hsp70 Activator

Purity >98%
Molecular Formula C23H22Cl2N2O5
Molecular Weight 477.34

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Activator
Solubility Soluble in DMSO (20 mg/ml)
Source Synthetic
Appearance White Solid
SMILES CC1=C(C(NC(=O)N1CCCC(=O)O)c2ccc(cc2Cl)Cl)C(=O)OCc3ccccc3
InChI InChI=1S/C23H22Cl2N2O5/c1-14-20(22(30)32-13-15-6-3-2-4-7-15)21(17-10-9-16(24)12-18(17)25)26-23(31)27(14)11-5-8-19(28)29/h2-4,6-7,9-10,12,21H,5,8,11,13H2,1H3,(H,26,31)(H,28,29)
InChIKey UHBVLBSCOSTTAV-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product 115-7C (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-123)

Biological Description

Alternative Names 4-(5-((benzyloxy)carbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid, SWO2
Research Areas Cancer, Heat Shock
Scientific Background 115-7c activates Hsp70 ATPase turnover rate and promotes Hsp70 substrate refolding. It binds to the IIA subdomain of DnaK and promotes the DnaK-DnaJ complex. Equivalent with SW02.
References 1. Wisen et al., (2010) ACS Chem. Biol., 5: 611-622.
2. Jinwal et al. (2009) J.Neurosci. 29:12079.
3. Chafekar et al. (2012) ACS Chem Biol. 7:1556.
4. Walter et al. (2011) J. Biol. Chem. 286:40486

Product Images

Chemical structure of 115-7C (SIH-123), a Hsp70 Activator. Molecular Formula: C₂₃H₂₂Cl₂N₂O₅. Molecular Weight: 477.34 g/mol.

Product Citations (1)

Other Citations

Hsp70 May Be a Molecular Regulator of Schistosome Host Invasion.

Ishida, K. and Jolly E.R. (2016) PLoS Negl Trop Dis. 10(9):e0004986.

PubMed ID: 27611863 Applications: In vitro activation

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