Apicidin

HDAC inhibitor

Catalog No. SIH-346

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CAS No. 183506-66-3
Molecular Forumla C34H49N5O6

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Overview

Product Name Apicidin
Description

HDAC inhibitor

Purity >98% (HPLC); NMR (conforms)
CAS No. 183506-66-3
Molecular Formula C34H49N5O6
Molecular Weight 623.8

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 10 mg/ml DMSO or 100% Ethanol
Source Synthetic
Appearance White Solid
SMILES CC[[email protected]](C)[[email protected]]1C(=O)N2CCCC[C@@H]2C(=O)N[[email protected]](C(=O)N[[email protected]](C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC
InChI InChI=1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-1
InChIKey JWOGUUIOCYMBPV-GMFLJSBRSA-N
Safety Phrases Classification: Toxic. May be harmful or fatal if inhaled, swallowed, or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H300+H310 – Fatal if swallowed or in contact with skin.
H330 – Fatal if inhaled
Precautionary Statements:
P260 – Do not breathe dust/fumes/gas/mist/vapours/spray
P264- Wash hands thoroughly after handling
P280 – Wear protective gloves/ Protective clothing
P284 – Wear respiratory protection
P302 + P350 – If on skin: Gently wash with plenty of soap and water.
P310 – Immediately call a poison center or doctor/ physician
Cite This Product Apicidin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-346)

Biological Description

Alternative Names (3S,6S,9S,15aR)-9-[(2S)-2-Butanyl]-6-[(1-methoxy-1H-indol-3-yl)methyl]-3-(6-oxooctyl)octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone; Cyclo(N-O-methyl-L-tryptophanyl-L Lisoleucinyl-Dpipecolinyl-L-2-amino-8-oxodecanoyl)
Research Areas Cancer, Cell Signaling, Epigenetics
PubChem ID 6918328
Scientific Background Cyclopeptide inhibitor of histone deactylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1? protein levels and transcriptional activity in human and mouse tumor cell lines. Cell permeable.
References 1. Darkin-Rattray S.J., et al. (1996) Proc. Natl. Acad. Sci. USA. 93: 13143.
2. Han J.W., et al. (2000) Cancer Res. 60: 6068.
3. Kim S.H., et al. (2007) Oncol. Rep. 17: 647.

Product Images

Chemical structure of Apicidin (SIH-346), a HDAC inhibitor. CAS #: 183506-66-3. Molecular Formula: C34H49N5O6 . Molecular Weight: 623.8 g/mol.

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