BIX-01294

HMT inhibitor

Catalog No. SIH-347

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CAS No. 935693-62-2
Molecular Forumla C28H38N6O2*3HCl

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Overview

Product Name BIX-01294
Description

HMT inhibitor

Purity >98%
CAS No. 935693-62-2
Molecular Formula C28H38N6O2*3HCl
Molecular Weight 600.02

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (100 mM) or Water (100 mM)
Source Synthetic
Appearance Cream solid
SMILES CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC.Cl.Cl.Cl
InChI InChI=1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)
InChIKey OSXFATOLZGZLSK-UHFFFAOYSA-N
Safety Phrases Classification: Caution – Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product BIX-01294 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-347)

Biological Description

Alternative Names 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride; N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine trihydrochloride
Research Areas Cancer, Cell Signaling, Epigenetics
PubChem ID 25150857
Scientific Background G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC values are 0.7 and 1.7 µM respectively) that displays no activity at other histone methyltransferases up to 37 µM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.
References 1. Kubicek S., et al. (2007) Mol Cell. 25(3): 473-481.
2. Shi Y., et al. (2008) Cell Stem Cell. 3(5): 568-574.
3. Chang Y., et al. (2009) Nat Struct Mol Biol. 16(3): 312-317.

Product Images

Chemical structure of BIX-01294 (SIH-347), a Histone methyltransferase inhibitor. CAS #: 935693-62-2. Molecular Formula: C28H38N6O2 * 3HCl. Molecular Weight: 600.02 g/mol.

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