Decitabine

DNA hypomethylation agent

Catalog No. SIH-352

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CAS No. 2353-33-5
Molecular Forumla C8H12N4O4

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Product Name Decitabine
Description

DNA hypomethylation agent

Purity >98% (TLC); NMR (Conforms)
CAS No. 2353-33-5
Molecular Formula C8H12N4O4
Molecular Weight 228.2

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 25 mg/ml DMSO, 11 mg/ml Water or Ethanol
Source Synthetic
Appearance White Solid
SMILES C1[C@@H]([[email protected]](O[[email protected]]1N2C=NC(=NC2=O)N)CO)O
InChI InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
InChIKey XAUDJQYHKZQPEU-KVQBGUIXSA-N
Safety Phrases Classification: Harmful – May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Statements: H341 – Suspected of causing genetic defects H360 – May damage fertility or the unborn child Precautionary Statements: P280 – Wear protective gloves/protective clothing/ eye protection/ face protection P308+313 – If exposed or concerned: Get Medical Advise/Attention
Cite This Product Decitabine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-352)

Biological Description

Alternative Names 5-Aza-2’-deoxycytidine; NSC-127716, 2'-Deoxy-5-azacytidine; 4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
Research Areas Cancer, Cell Signaling, Epigenetics
PubChem ID 451668
Scientific Background Inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells. Antitumor agent. Cell permeable.
References 1. Bender C.M., et al. (1998) Cancer Res. 58: 95. 2. El-Serafi A.T., et al. (2011) Differentiation 81: 35.

Product Images

<p>Chemical structure of Decitabine (SIH-352), a DNA hypomethylation agent. CAS #: 2353-33-5. Molecular Formula: C8H12N4O4. Molecular Weight: 228.2 g/mol.</p>

Chemical structure of Decitabine (SIH-352), a DNA hypomethylation agent. CAS #: 2353-33-5. Molecular Formula: C8H12N4O4. Molecular Weight: 228.2 g/mol.

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