DNA hypomethylation agent

Catalog No. SIH-352

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CAS No. 2353-33-5
Molecular Forumla C8H12N4O4

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SKU: SIH-352 Categories: , .

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Product Name Decitabine

DNA hypomethylation agent

Purity >98% (TLC); NMR (Conforms)
CAS No. 2353-33-5
Molecular Formula C8H12N4O4
Molecular Weight 228.2


Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 25 mg/ml DMSO, 11 mg/ml Water or Ethanol
Source Synthetic
Appearance White Solid
SMILES C1[C@@H]([[email protected]](O[[email protected]]1N2C=NC(=NC2=O)N)CO)O
InChI InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
Safety Phrases Classification: Harmful – May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Statements:
H341 – Suspected of causing genetic defects
H360 – May damage fertility or the unborn child
Precautionary Statements:
P280 – Wear protective gloves/protective clothing/ eye protection/ face protection
P308+313 – If exposed or concerned: Get Medical Advise/Attention
Cite This Product Decitabine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-352)

Biological Description

Alternative Names 5-Aza-2’-deoxycytidine; NSC-127716, 2'-Deoxy-5-azacytidine; 4-Amino-1-(2-deoxy-?-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one
Research Areas Cancer, Cell Signaling, Epigenetics
PubChem ID 451668
Scientific Background Inhibits DNA methyltransferase. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Stimulates osteogenic differentiation of human bone marrow stromal cells. Antitumor agent. Cell permeable.
References 1. Bender C.M., et al. (1998) Cancer Res. 58: 95.
2. El-Serafi A.T., et al. (2011) Differentiation 81: 35.

Product Images

Chemical structure of Decitabine (SIH-352), a DNA hypomethylation agent. CAS #: 2353-33-5. Molecular Formula: C8H12N4O4. Molecular Weight: 228.2 g/mol.

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