Lysophosphatidic Acid, Sodium Salt

Autophagy inhibitor

Catalog No. SIH-403

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CAS No. 22556-62-3
Molecular Forumla C21H41O7P*Na

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Overview

Product Name Lysophosphatidic Acid, Sodium Salt
Description

Autophagy inhibitor

Purity >98%
CAS No. 22556-62-3
Molecular Formula C21H41O7P*Na
Molecular Weight 458.5

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO (1 mg/ml) and warm water (10 mg/ml).
Source Synthetic
Appearance White powder.
SMILES C(O[P](=O)(O)O)C(O)COC(=O)CCCCCCCC=C/CCCCCCCC
InChI InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-/t20-/m1/s1
InChIKey WRGQSWVCFNIUNZ-GDCKJWNLSA-N
Safety Phrases Classification: Not WHMIS controlled.
Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Cite This Product Lysophosphatidic Acid, Sodium Salt (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-403)

Biological Description

Alternative Names Oleoyl-lysophosphatidic acid sodium salt
Research Areas Cancer, Autophagy
PubChem ID 5311263
Scientific Background Oleoyl-lysophosphatidic acid is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. It has been shown to induce cellular functions such as cell proliferation and migration, and ICAM-1, IL-8 and MCP-1 expression. Lysophosphatidic acid has also been observed to inhibit autophagy in cells under starvation conditions by inhibiting autophagosome formation.
References 1. van Corven E.J., et al. (1992) Biochem J. 281(Pt 1): 163-9.
2. Chang C.L., et al. (2007) Autophagy. 3(3): 268-70.

Product Images

Chemical structure of Lysophosphatidic Acid (SIH-403), a Autophagy inhibitor. CAS #: 22556-62-3 . Molecular Formula: C21H41O7P. Molecular Weight: 436.5245 g/mol.

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