Mifepristone (RU486)

Glucocorticoid antagonist

Catalog No. SIH-211

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CAS No. 84371-65-3
Molecular Forumla C29H35NO2

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Product Name Mifepristone (RU486)
Description

Glucocorticoid antagonist

Purity >98%
CAS No. 84371-65-3
Molecular Formula C29H35NO2
Molecular Weight 429.6

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 100 mM in DMSO, and to 50 mM in ethanol
Source Synthetic
Appearance Yellow solid
SMILES CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)
InChIKey VKHAHZOOUSRJNA-GCNJZUOMSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R60- May impair fertility R61- May cause harm to the unborn child Hazard Phrases: H360 Precautionary Phrases: P201-P308 + P313
Cite This Product Mifepristone (RU486) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-211)

Biological Description

Alternative Names (11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propyn-1-yl)estra-4,9-dien-3-one, RU486, RU 38486
Research Areas Cancer, Apoptosis
PubChem ID 55245
Scientific Background Mifepristone is a progesterone receptor antagonist used as an abortifacient. It is also an antiglucocorticoid and an antiandrogen. Its relative binding affinity at the progesterone receptor is twice that of progesterone, its affinity at the glucocorticoid receptor is 3x that of dexamethasone, and more than 10 times that of cortisol (1).
References 1. Heikinheim O., Kekkonen R. and Lahteenmaki P. (2003) Contraception. 68(6): 421-426.

Product Images

<p>Chemical structure of Mifepristone (RU486) (SIH-211), a Glucocorticoid antagonist. CAS #: 84371-65-3. Molecular Formula: C29H35NO2 . Molecular Weight: 429.6 g/mol.</p>

Chemical structure of Mifepristone (RU486) (SIH-211), a Glucocorticoid antagonist. CAS #: 84371-65-3. Molecular Formula: C29H35NO2 . Molecular Weight: 429.6 g/mol.

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