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| Product Name | Pifithrin mu |
| Description |
Hsp70 inhibitor |
| Purity | >98% |
| CAS No. | 64984-31-2 |
| Molecular Formula | C8H7NO2S |
| Molecular Weight | 181.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in ethanol (110 mM) and in DMSO (110 mM) |
| Source | Synthetic |
| Appearance | White to off-white solid |
| SMILES | C1=CC=C(C=C1)C#CS(=O)(=O)N |
| InChI | InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11) |
| InChIKey | ZZUZYEMRHCMVTB-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes Hazard Phrases: H302-H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338 |
| Cite This Product | Pifithrin mu (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-325) |
Biological Description
| Alternative Names | 2-Phenylethynesulfonamide, PFTµ |
| Research Areas | Cancer, Heat Shock |
| PubChem ID | 327653 |
| Scientific Background | Pifithrin mu selectively interacts with HSP70, disrupting its association with co-chaperones and substrate proteins. It inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. This dual action promotes apoptosis and modulates stress response pathways. In neurodegenerative research, Pifithrin mu is used to study protein folding, mitochondrial integrity, and apoptotic regulation. |
| References | 1. Leu J.L., et al. (2009) Mol. Cell. 36: 15. |
Product Images
Chemical structure of Pifithrin mu (SIH-325), a Hsp70 inhibitor. CAS #: 64984-31-2. Molecular Formula: C8H7NO2S. Molecular Weight: 181.2 g/mol.
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Based on validation through cited publications.