Pifithrin mu

Hsp70 inhibitor

Catalog No. SIH-325

5 out of 5 based on 1 customer rating
CAS No. 64984-31-2
Molecular Forumla C8H7NO2S
5 out of 5 based on 1 customer rating
(1 customer review)

USD $40.00USD $149.00

SKU: SIH-325 Categories: , .

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Overview

Product Name Pifithrin mu
Description

Hsp70 inhibitor

Purity >98%
CAS No. 64984-31-2
Molecular Formula C8H7NO2S
Molecular Weight 181.2

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in ethanol (110 mM) and in DMSO (110 mM)
Source Synthetic
Appearance White to off-white solid
SMILES C1=CC=C(C=C1)C#CS(=O)(=O)N
InChI InChI=1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChIKey ZZUZYEMRHCMVTB-UHFFFAOYSA-N
Safety Phrases Classification: Caution: Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Hazard Phrases:
H302-H315-H319-H335
Precautionary Phrases:
P261-P305 + P351 + P338
Cite This Product Pifithrin mu (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-325)

Biological Description

Alternative Names 2-Phenylethynesulfonamide, PFTµ
Research Areas Cancer, Heat Shock
PubChem ID 327653
Scientific Background Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and is cell permeable. Also, inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
References 1. Leu J.L., et al. (2009) Mol. Cell. 36: 15.

Product Images

Chemical structure of Pifithrin mu (SIH-325), a Hsp70 inhibitor. CAS #: 64984-31-2. Molecular Formula: C8H7NO2S. Molecular Weight: 181.2 g/mol.

Product Citations (2)

Other Citations

HSP70 and HSP90 Differentially Regulate Translocation of Extracellular Antigen to the Cytosol for Cross-Presentation.

Kato. Y. et al. (2012) Autoimmune Dis. 2012:745962.

PubMed ID: 23050124 Applications: HSP70 inhibitor assay

Reviews

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