Sodium Valproate

HDAC inhibitor

Catalog No. SIH-357

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CAS No. 1069-66-5
Molecular Forumla C8H15NaO2

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Overview

Product Name Sodium Valproate
Description

HDAC inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 1069-66-5
Molecular Formula C8H15NaO2
Molecular Weight 166.2

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in 50 mg/ml Water
Source Synthetic
Appearance White Solid
SMILES CCCC(CCC)C(=O)[O-].[Na+]
InChI InChI=1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
InChIKey AEQFSUDEHCCHBT-UHFFFAOYSA-M
Safety Phrases Classification: Caution- Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product Sodium Valproate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-357)

Biological Description

Alternative Names 2-Propylpentanoic acid Na
Research Areas Cancer, Cell Signaling, Epigenetics
PubChem ID 16760703
Scientific Background Histone deacetylase inhibitor (IC50=400 µM). Demonstrates neuroprotective, anticancer and anti-inflammatory activity. Inhibits A? production and neuritic plaque formation in Alzheimer’s mouse models. Clinically useful anticonvulsant.
References 1. Phiel C.J., et al. (2001) J. Biol. Chem. 276: 36734.
2. Kim H.J., et al. (2007) J. Pharmacol. Exp. Ther. 321: 892.
3. Qing H., et al. (2008) J. Exp. Med. 205: 2781.

Product Images

Chemical structure of Sodium Valproate (SIH-357), a HDAC inhibitor. CAS #: 1069-66-5. Molecular Formula: C8H15NaO2 . Molecular Weight: 166.2 g/mol.

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