Thiolutin

RNA polymerase inhibitor

Catalog No. SIH-375

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CAS No. 87-11-6
Molecular Forumla C8H8N2O2S2

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Product Name Thiolutin
Description

RNA polymerase inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 87-11-6
Molecular Formula C8H8N2O2S2
Molecular Weight 228.3

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility May be dissolved in DMSO (15 mg/ml)
Source Synthetic
Appearance Yellow powder
SMILES CC(=O)NC1=C2C(=CSS2)N(C1=O)C
InChI InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11)
InChIKey MHMRAFONCSQAIA-UHFFFAOYSA-N
Safety Phrases Classification: Danger. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H300 – Fatal if swallowed H330 – Fatal if inhaled Precautionary Phrases: P260 – Do not breathe dust/fume/gas/mist/vapours/spray P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician P405 – Store locked up
Cite This Product Thiolutin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-375)

Biological Description

Alternative Names N-(4,5-Dihydro-4-methyl-5-oxo-1,2-d¬ithiolo[4,3-b]pyrrol-6-yl)acetamide
Research Areas Cell Signaling, Epigenetics
PubChem ID 6870
Scientific Background Thiolutin is a sulfur antibiotic. Studies show the potential transcriptional inhibition on yeast degradation. By calculating the mRNA decay rates of transcription at different times after inhibition, it was evident that the effect of Thiolutin on the various degradation pathways of mRNA compromises the stability of the mRNA and the mechanism of gene expression (1). In pharmacology is known to inhibit endothelial cell adhesion by perturbing Hsp 27 interactions with components of the actin and intermediate filament cytoskeleton (2). Studies shown the inhibition of tumor cell-induced angionegesis in vivo, adhesion of endothelial cells to vitronectin ( IC50=0.83 µM) (3). Potentially inhibits developmental angiogenesis in zebrafish (2). Cell permeable. Active in vivo. Looking for more information on HSP27? Visit our new HSP27 Scientific Resource Guide at http://www.HSP27.com.
References 1. Pelechano V. and Perez-Ortin J. (2008) Yeast 25: 85-92. 2. Jia Y., et al. (2010) Cell Stress Chaperones 15: 165. 3. Minamiguchi K., et al. (2001) International J. Cancer. 93: 307.

Product Images

<p>Chemical structure of Thiolutin (SIH-375), a HSP27 perturbing agent. CAS #: 87-11-6. Molecular Formula: C8H8N2O2S2. Molecular Weight: 228.3 g/mol.</p>

Chemical structure of Thiolutin (SIH-375), a HSP27 perturbing agent. CAS #: 87-11-6. Molecular Formula: C8H8N2O2S2. Molecular Weight: 228.3 g/mol.

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