|Shipping Temperature||Shipped Ambient|
|Solubility||Soluble in warm water (2 mg/ml)|
|Appearance||Orange red solid|
|Safety Phrases||Classification: Caution: Substance not yet fully tested.
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
|Cite This Product||YM-01 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-121)|
|Alternative Names||2-((Z)-((E)-3-ethyl-5-(3-methylbenzo[d]thiazol-2(3H)-ylidene)-4-oxothiazolidin-2-ylidene)methyl)-1-methylpyridin-1-ium chloride; YM-1|
|Research Areas||Cancer, Heat Shock|
|Scientific Background||YM-01 is an allosteric Hsp70 inhibitor. It binds with in Hsp70's nucleotide binding domain, adjacent to ATP/ADP binding pocket. It inhibits J-stimulated ATP turnover rate. It blocks Hsc70-bag1 interaction both in vitro and in vivo and enhances binding of Hsp70 to misfolded proteins. It reduces tau levels in tau-overexpressed HeLa cells, endogenous tau in neuroblastoma cells, and endogenous tau in primary neuron from rTg4510 mice, with EC50's of low micromolar. It recovers long-term potentiation deficits in brain slices from rTg4510 mice. It also has anti-cancer activity, with an EC50 value of low micromolar against several cancer cell lines. It destabilizes oncoproteins in cells, including Akt and Raf-1. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.|
|References||1. Wang et al., 2013 Nature Chem. Biol. 9: 112-118.
2. Abisambra et al., 2013 Biol. Psychiatry, 74: 367-374.
3. Koren et al. PLoS One 7:e35566.
4. Morishima et al. 2011 Biochemistry. 50: 7146.
5. Davis et al. 2012 J. Immunol. 189: 4488.
Currently there are no citations for this product.