SOD1

StressMarq Biosciences is a leading provider of high-quality fibrillar, oligomeric, and monomeric protein preparations—including alpha synucleintauamyloid betaTDP-43SOD1, TTR and more—designed to support cutting-edge neurodegenerative disease research. With a focus on pathology-inducing protein aggregates, our products support the development of robust disease models and accelerate drug discovery for conditions such as Alzheimer’s, Parkinson’s, and ALS. StressMarq is committed to scientific excellence— empowering researchers worldwide with tools that accelerate discovery and translational research.

SOD1 Pre-formed Fibrils (PFFs) & Monomers

Superoxide dismutase 1 (SOD1) is a copper/zinc-containing enzyme that plays a critical role in cellular antioxidant defense by catalyzing the conversion of superoxide radicals into oxygen and hydrogen peroxide. Present in nearly all mammalian cells, SOD1 helps maintain redox balance and protect against oxidative damage. In Amyotrophic Lateral Sclerosis (ALS), mutations and misfolding of SOD1 lead to the formation of neurotoxic aggregates that contribute to motor neuron degeneration.

StressMarq Biosciences produces SOD1 protein aggregates, including monomeric and fibrillar forms, optimized for ALS research. These reagents support studies on protein misfolding, oxidative stress, and neurotoxicity, enabling the development of disease models and the screening of potential therapeutics. Our SOD1 constructs are validated for activity and reproducibility, helping researchers advance translational research in neurodegeneration.


StressMarq manufactures SOD1 fibrils and monomers for use in neurodegenerative disease research.

StressMarq’s SOD1 fibrils seed the aggregation of SOD1 monomers, demonstrated through increased fluorescence in Thioflavin T assays.

TEM of human SOD1 pre-formed fibrils (PFFs) (SPR-470)

TEM of human SOD1 Pre-formed Fibrils (PFFs) (PFFs)

Thioflavin T assay of SOD1 fibrils and monomers

Thioflavin T assay of SOD1 pre-formed fibrils (PFFs) (SPR-470) combined with SOD1 monomers (SPR-435). Fibrils seed the aggregation of monomers, leading to an increase in Thioflavin T fluorescence.

 

1. Adachi T., et al. (1992). Clin. Chim. Acta. 212: 89-102.
2. Barrister J.V., et al. (1987). Crit. Rev. Biochem. 22:111-180.
3. Furukawa Y., O’Halloran T. (2006). Antioxidants & Redo Signaling. Vol 8, No 5,6.
4. Gao B., et al. (2003). Am J Physiol Lung Cell Mol Physiol 284: L917-L925.
5. Hassan H.M. (1988). Free Radical Biol. Med. 5: 377-385.

Supplemental Learning Materials

Technical Support Resources

Selected Publications from the StressMarq Blog

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  Featured SOD Products

  • SOD1 Pre-formed Fibrils

    Human Recombinant Superoxide Dismutase 1 (SOD1) PFFs

    Catalog No. SPR-470

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    Expression System E. coli
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    SPR-470_SOD1-Protein-TEM-2.png
    TEM of human SOD1 pre-formed fibrils (PFFs) (SPR-470)Thioflavin T assay of SOD1 fibrils and monomers
  • SOD1 Monomers

    Human Recombinant Superoxide Dismutase 1 (SOD1) Monomers

    Catalog No. SPR-435

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    Expression System E. coli
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    SPR-435_SOD1-Protein-SDS-PAGE-1.png
    Thioflavin T assay of SOD1 fibrils and monomers
  • Anti-SOD1 (Cu/Zn) Antibody

    Rabbit Anti-Human SOD1 (Cu/Zn) Polyclonal

    Catalog No. SPC-116

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    Species Reactivity Hu, Rt, Ms, Bv, Mk, Inv, Co, Dg, Hm, Pg, Rb, Sh, Xe, Mlsk, Fs
    Applications WB IHC ICC/IF FCM IP
    SKU: SPC-116 Categories: ,

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    SPC-116_SOD1_Antibody_IHC_Human_Placenta_1.png
    Rabbit Anti-SOD1 (Cu/Zn) Antibody used in Western blot (WB) on Human Cell line lysates (SPC-116)
  • Anti-SOD1 (EDI) Antibody

    Rabbit Anti-Human SOD1 (EDI) Polyclonal

    Catalog No. SPC-206

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    Species Reactivity Hu, Ms, Rt, Pg
    Applications WB IHC ICC/IF FCM IP
    SKU: SPC-206 Categories: ,

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    SPC-206-SOD1-EDI-Antibody-WB-Mouse-Lung-1.png
  • Anti-SOD1 (UbetaB) Antibody

    Rabbit Anti-Human SOD1 (UbetaB) Polyclonal

    Catalog No. SPC-205

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    Species Reactivity Hu, Ms, Rt
    Applications WB IHC ICC/IF FCM IP
    SKU: SPC-205 Categories: ,

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    SPC-205_SOD1-UBB_Antibody_ICC-IF_Human_HeLa-Cells_100x_Composite.png
    Rabbit Anti-SOD1 (UbetaB) Antibody used in Western blot (WB) on Hela cells, Brain, Lung (SPC-205)