1-Deoxynojirimycin

Glycosidase inhibitor

Catalog No. SIH-547

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CAS No. 19130-96-2
Molecular Formula C6H13NO4
SKU: SIH-547 Categories: ,

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SIH-547-1-Deoxynojirimycin-Chemical-Structure.png
Product Name 1-Deoxynojirimycin
Description

Glycosidase inhibitor

Purity >98% (TLC); NMR (Conforms)
CAS No. 19130-96-2
Molecular Formula C6H13NO4
Molecular Weight 163.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Blue Ice or 4ºC
Product Type Inhibitor
Solubility May be dissolved in water (25 mg/ml)
Source Synthetic
Appearance White powder
SMILES C1C(C(C(C(N1)CO)O)O)O
InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
InChIKey LXBIFEVIBLOUGU-JGWLITMVSA-N
Safety Phrases WHMIS Classification:
Not Rated. Not a hazardous substance or mixture.

HMIS Classification:
Health hazard: 0
Flammability: 0
Physical hazards: 0

Potential Health Effects:
Inhalation - May be harmful if inhaled. May cause respiratory tract irritation.
Skin - May be harmful if absorbed through skin. May cause skin irritation.
Eyes - May cause eye irritation.
Ingestion - May be harmful if swallowed.
Cite This Product 1-Deoxynojirimycin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-547)

Biological Description

Alternative Names 1-deoxymannojirimycin, 1-DEOXYNOJIRIMYCIN, 19130-96-2, DUVOGLUSTAT, (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, Moranoline, Deoxynojirimycin
Research Areas Immunology
PubChem ID 29435
Scientific Background 1-Deoxynojirimycin (DNJ) is a naturally occurring iminosugar best known for its potent inhibition of α-glucosidases, enzymes critical to glycoprotein processing and carbohydrate metabolism. While DNJ has been extensively studied in the context of metabolic disorders such as diabetes and lysosomal storage diseases, its relevance to neuroscience is gaining attention. In neurodegenerative disease research, DNJ’s ability to modulate glycosphingolipid metabolism positions it as a promising candidate for targeting pathological protein aggregation and lysosomal dysfunction—hallmarks of disorders like Parkinson’s and Gaucher disease. Recent studies suggest that DNJ and its derivatives may influence neuroinflammatory pathways and neuronal survival by altering glycan processing, potentially mitigating neurodegeneration. Its role in modulating endoplasmic reticulum stress and autophagy further underscores its therapeutic potential in neurodegenerative contexts. Additionally, DNJ’s capacity to cross the blood-brain barrier enhances its appeal for central nervous system applications. Beyond neuroscience, DNJ remains a cornerstone compound in glycobiology and antiviral research, particularly for its ability to interfere with viral glycoprotein maturation.

Product Images

<p>Chemical structure of 1-Deoxynojirimycin (SIH-547), a Glycosidase inhibitor. CAS #: 19130-96-2. Molecular Formula: C6H13NO4. Molecular Weight: 163.2 g/mol.</p>

Chemical structure of 1-Deoxynojirimycin (SIH-547), a Glycosidase inhibitor. CAS #: 19130-96-2. Molecular Formula: C6H13NO4. Molecular Weight: 163.2 g/mol.

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