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| Product Name | 2-APB |
| Description |
TRP blocker |
| Purity | >98% |
| CAS No. | 524-95-8 |
| Molecular Formula | C14H16BNO |
| Molecular Weight | 225.1 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN |
| InChI | InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2 |
| InChIKey | BLZVCIGGICSWIG-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302-H315-H317-H318-H335 Precautionary Phrases: P261-P280-P305 + P351 + P338 |
| Cite This Product | 2-APB (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-316) |
Biological Description
| Alternative Names | 2-Aminoethoxydiphenylborane |
| Research Areas | Ion Channels, Neuroscience |
| PubChem ID | 1598 |
| Scientific Background | 2-APB is a chemical that acts to inhibit IP3 receptors (1) and TRP channels (2). It is used to manipulate intracellular release of calcium ions and modify TRP channel activity. There is also evidence that 2-APB acts directly to inhibit gap junctions made of connexin26 or connexin32 (3). |
| References |
1. Diver J.M., Sage S.O., Rosado J.A. (2001) Cell Calcium. 30(5): 323-329 2. Xu S.Z., et al. (2005) Br J Pharamcol. 145(4): 320-328. 3. Tao L., and Harris A.L. (2007) Mol Pharmacol. 71(2): 570-579. |
Product Images
Chemical structure of 2-APB (SIH-316), a TRP blocker. CAS #: 524-95-8. Molecular Formula: C14H16BNO. Molecular Weight: 225.1 g/mol.
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Based on validation through cited publications.