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| Product Name | 6-ECDCA |
| Description |
FXR agonist |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 459789-99-2 |
| Molecular Formula | C26H44O4 |
| Molecular Weight | 420.6 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | May be dissolved in DMSO (50 mg/ml) and ethanol (30 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | CCC1C2CC(CCC2(C3CCC4(C(C3C1O)CCC4C(C)CCC(=O)O)C)C)O |
| InChI | InChI=1S/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26- |
| InChIKey | ZXERDUOLZKYMJM-ZWECCWDJSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | 6-ECDCA (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-590) |
Biological Description
| Alternative Names | 6-Ethylchenodeoxycholic acid; 3α,7α-Dihydroxy-6α-ethyl-5β-cholan-24-oic acid; Obeticholic acid |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 447715 |
| Scientific Background |
6-ECDCA, also known as Obeticholic Acid, is a potent and selective agonist of the farnesoid X receptor (FXR). It exhibits anti-inflammatory, anti-cholestatic, and autophagy-inducing properties. While primarily studied in liver diseases such as primary biliary cholangitis, its ability to modulate metabolic and inflammatory pathways has sparked interest in neurodegenerative disease research. FXR signaling intersects with pathways involved in neuroinflammation, lipid metabolism, and mitochondrial function, making 6-ECDCA a candidate for exploring therapeutic strategies in disorders like Alzheimer’s and Huntington’s disease. |
Product Images
Chemical structure of 6-ECDCA (SIH-590), a FXR Agonist. CAS #: 459789-99-2. Molecular Formula: C26H44O4. Molecular Weight: 420.6 g/mol.
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