6BIO

PDK1 kinase inhibitor

Catalog No. SIH-422

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CAS No. 667463-62-9
Molecular Formula C16H10BrN3O2
SKU: SIH-422 Categories: ,

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SIH-422_6BIO_Chemical_Structure.png
Product Name 6BIO
Description

PDK1 kinase inhibitor

Purity >98% (HPLC)
CAS No. 667463-62-9
Molecular Formula C16H10BrN3O2
Molecular Weight 356.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble to 10 mM in DMSO and to 10 mM in ethanol
Source Synthetic
Appearance Dark red solid
SMILES C1=CC=C2C(=C1)/C(=NO)/C(=C/3C4=C(C=C(C=C4)Br)NC3=O)/N2
InChI InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,20,22H,(H,19,21)/b15-13+
InChIKey WNWSUJQVZJJGLF-FYWRMAATSA-N
Safety Phrases Classification:
Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity-single exposure ( Category 3 ), Respiratory system, H335

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supplemental first aid instru
ctions on this label).
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product 6BIO (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-422)

Biological Description

Alternative Names (2’Z,3’E)-6-Bromoindirubin-3′-oxime, 6-BIO, 6BIO, (3Z)-6-Bromo-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Research Areas Cell Signaling
PubChem ID 11405589
Scientific Background 6BIO is an inhibitor of phosphoinositide-dependent kinase 1 (PDK1), and a potent, reversible and ATP-competitive inhibitor of glycogen synthase kinase-3α/β (GSK-3α/β). It maintains self-renewal and pluripotency in embryonic stem cells via activation of the Wnt signaling pathway.
References 1. Valerio A., et al. (2011) J. Neurochem. 116(6): 1148–1159.
2. Yasuhara R., et al. (2010) J. Biol. Chem. 285(1): 317–327.
3. Meijer L., et al. (2003) Chem. & Bio. 10(12): 1255–1266.

Product Images

<p>Chemical structure of 6BIO (SIH-422), a ESC self-renewal. CAS #: 667463-62-9. Molecular Formula: C16H10BrN3O2. Molecular Weight: 356.2 g/mol.</p>

Chemical structure of 6BIO (SIH-422), a ESC self-renewal. CAS #: 667463-62-9. Molecular Formula: C16H10BrN3O2. Molecular Weight: 356.2 g/mol.

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