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| Product Name | A-803467 |
| Description |
NaV1.8 blocker |
| Purity | >98% |
| CAS No. | 944261-79-4 |
| Molecular Formula | C19H16ClNO4 |
| Molecular Weight | 357.79 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| Source | Synthetic |
| Appearance | Beige Solid |
| SMILES | COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl)OC |
| InChI | InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22) |
| InChIKey | VHKBTPQDHDSBSP-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Hazard Phrases: H302 |
| Cite This Product | A-803467 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-304) |
Biological Description
| Alternative Names | 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide |
| Research Areas | Ion Channels, Neuroscience, Sodium Channels |
| PubChem ID | 16038374 |
| Scientific Background | A-803467 is a selective blocker of Nav1.8 sodium channels, which are predominantly expressed in peripheral sensory neurons. It effectively reduces thermal hyperalgesia and mechanical allodynia in models of inflammatory and neuropathic pain. In neuroscience, A-803467 is used to study pain signaling pathways and the role of Nav1.8 in sensory neuron excitability and chronic pain conditions. |
| References | 1. Rush A.M., Cummins T.R. (2007) Mol Interv. 7(4): 192-195. |
Product Images
Chemical structure of A-803467 (SIH-304), a NaV1.8 blocker. CAS #: 944261-79-4. Molecular Formula: C19H16ClNO4. Molecular Weight: 357.79 g/mol.
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