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| Product Name | A 769662 |
| Description |
AMPK kinase activator |
| Purity | >99% (HPLC) |
| CAS No. | 844499-71-4 |
| Molecular Formula | C20H12N2O3S |
| Molecular Weight | 360.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| Source | Synthetic |
| Appearance | Off-white solid |
| SMILES | C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O |
| InChI | InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25) |
| InChIKey | CTESJDQKVOEUOY-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | A 769662 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-490) |
Biological Description
| Alternative Names | A-769662 |
| Research Areas | Cell Signaling |
| PubChem ID | 54708532 |
| Scientific Background | A 769662 is a potent and reversible activator of AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis. In neurodegenerative disease research, A 769662 is used to explore the role of AMPK in neuronal metabolism, autophagy, and stress resistance. Activation of AMPK by A 769662 has been shown to inhibit fatty acid synthesis and reduce plasma glucose and triglyceride levels, making it a promising compound for studying metabolic dysfunction in Alzheimer’s and Parkinson’s disease. |
| References |
1. Sanders M.J., et al. (2007) J. Biol. Chem. 282(45): 32539–32548. 2. Göransson O., et al. (2007) J. Biol. Chem. 282(45): 32549–32560. |
Product Images
Chemical structure of A 769662 (SIH-490), a AMPK kinase activator. CAS #: 844499-71-4. Molecular Formula: C20H12N2O3S. Molecular Weight: 360.4 g/mol.
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