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| Product Name | Isopimaric acid (Discontinued) |
| Description |
Potassium Channel Activtor |
| Purity | >98% (GC; TLC); NMR (Conforms) |
| CAS No. | 5835-26-7 |
| Molecular Formula | C20H30O2 |
| Molecular Weight | 302.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | May be dissolved in DMSO (40 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | [H][C@]12CC[C@@](C)(CC1=CC[C@@]3([H])[C@@](C)(CCC[C@]23C)C(O)=O)C=C |
| InChI | 1S/C20H30O2/c1-5-18(2)12-9-15-14(13-18)7-8-16-19(15,3)10-6-11-20(16,4)17(21)22/h5,7,15-16H,1,6,8-13H2,2-4H3,(H,21,22)/t15-,16+,18-,19+,20+/m0/s1 |
| InChIKey | MXYATHGRPJZBNA-KRFUXDQASA-N |
| Safety Phrases |
Hazard statement(s): H410 Very toxic to aquatic life with long lasting effects. Precautionary statement(s): P273 Avoid release to the environment. P391 Collect spillage. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | Isopimaric acid (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-592) |
Biological Description
| Alternative Names | (1R,4aR,4bS,7S,10aR)-7-Ethenyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-1-phenanthrenecarboxylic acid |
| Research Areas | Alzheimer's Disease, Ion Channels, Neuroscience, Neurotransmission, Potassium Channels, Voltage-Gated Potassium Channels |
| PubChem ID | 442048 |
| Scientific Background | Isopimaric acid acts as a large conductance Ca2+-activated K+ channel (BK channel) opener. It improves spatial and non-spatial memory in Alzheimer’s 3xTg mouse models. |
| References | 1. Kaczorowski G.J., et al. (1996) 28(3): 255-267. 2. Wang L., et al. (2015) Neuropharm. 92: 8-15. |
Product Images
Chemical structure of Isopimaric acid (SIH-592), a Potassium Channel Activtor. CAS #: . Molecular Formula: C20H30O4. Molecular Weight: 302.5 g/mol.
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