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| Product Name | Piceatannol |
| Description |
SIRT1 activator |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 10083-24-6 |
| Molecular Formula | C14H12O4 |
| Molecular Weight | 244.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Activator |
| Solubility | Soluble in 10 mg/ml DMSO or 10 mg/ml Ethanol |
| Source | Synthetic |
| Appearance | Light Pink Solid |
| SMILES | C1=CC(=C(C=C1/C=C/C2=CC(=CC(=C2)O)O)O)O |
| InChI | InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+ |
| InChIKey | CDRPUGZCRXZLFL-OWOJBTEDSA-N |
| Safety Phrases |
Classification: Caution- Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes |
| Cite This Product | Piceatannol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-358) |
Biological Description
| Alternative Names | 3,3′,4,5′-Tetrahydroxy-transstilbene; 4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-1,2-benzenediol |
| Research Areas | Cell Signaling |
| PubChem ID | 667639 |
| Scientific Background |
Piceatannol, a naturally occurring analog of resveratrol, is gaining recognition in neuroscience for its neuroprotective potential. It inhibits nonreceptor tyrosine kinases Syk and Lyk (IC50 ~10 µM) and activates Sirt1, a sirtuin linked to cellular longevity and neuroprotection. These dual actions suggest a role in modulating neuroinflammatory pathways and oxidative stress—key contributors to neurodegenerative diseases such as Alzheimer’s and Parkinson’s. While traditionally cited in cancer and immunology research, Piceatannol’s emerging relevance in neuronal health highlights its value in developing targeted therapies for cognitive decline and age-related neurodegeneration. |
| References |
1. Seow C.J., et al. (2002) Eur. J. Pharmacol. 443: 189. 2. Howitz K.T., et al. (2003) Nature 425: 191. |
Product Images
Chemical structure of Piceatannol (SIH-358), a SIRT1 activator. CAS #: 10083-24-6. Molecular Formula: C14H12O4 . Molecular Weight: 244.2 g/mol.
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