Piceatannol

SIRT1 activator

Catalog No. SIH-358

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CAS No. 10083-24-6
Molecular Formula C14H12O4
SKU: SIH-358 Categories: ,

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SIH-358_Piceatannol_Chemical_Structure.png
Product Name Piceatannol
Description

SIRT1 activator

Purity >98% (TLC); NMR (Conforms)
CAS No. 10083-24-6
Molecular Formula C14H12O4
Molecular Weight 244.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Activator
Solubility Soluble in 10 mg/ml DMSO or 10 mg/ml Ethanol
Source Synthetic
Appearance Light Pink Solid
SMILES C1=CC(=C(C=C1/C=C/C2=CC(=CC(=C2)O)O)O)O
InChI InChI=1S/C14H12O4/c15-11-5-10(6-12(16)8-11)2-1-9-3-4-13(17)14(18)7-9/h1-8,15-18H/b2-1+
InChIKey CDRPUGZCRXZLFL-OWOJBTEDSA-N
Safety Phrases Classification: Caution- Substance not yet fully tested.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with skin and eyes
Cite This Product Piceatannol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-358)

Biological Description

Alternative Names 3,3′,4,5′-Tetrahydroxy-transstilbene; 4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-1,2-benzenediol
Research Areas Cell Signaling
PubChem ID 667639
Scientific Background Piceatannol, a naturally occurring analog of resveratrol, is gaining recognition in neuroscience for its neuroprotective potential. It inhibits nonreceptor tyrosine kinases Syk and Lyk (IC50 ~10 µM) and activates Sirt1, a sirtuin linked to cellular longevity and neuroprotection.

These dual actions suggest a role in modulating neuroinflammatory pathways and oxidative stress—key contributors to neurodegenerative diseases such as Alzheimer’s and Parkinson’s. While traditionally cited in cancer and immunology research, Piceatannol’s emerging relevance in neuronal health highlights its value in developing targeted therapies for cognitive decline and age-related neurodegeneration.
References 1. Seow C.J., et al. (2002) Eur. J. Pharmacol. 443: 189.
2. Howitz K.T., et al. (2003) Nature 425: 191.

Product Images

<p>Chemical structure of Piceatannol (SIH-358), a SIRT1 activator. CAS #: 10083-24-6. Molecular Formula: C14H12O4 . Molecular Weight: 244.2 g/mol.</p>

Chemical structure of Piceatannol (SIH-358), a SIRT1 activator. CAS #: 10083-24-6. Molecular Formula: C14H12O4 . Molecular Weight: 244.2 g/mol.

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