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| Product Name | AG 494 |
| Description |
EGFR kinase inhibitor |
| Purity | >98% (TLC) |
| CAS No. | 133550-35-3 |
| Molecular Formula | C16H12N2O3 |
| Molecular Weight | 280.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | C1=CC=C(C=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N |
| InChI | InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+ |
| InChIKey | HKHOVJYOELRGMV-XYOKQWHBSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | AG 494 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-491) |
Biological Description
| Alternative Names | AG-494, (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 5328771 |
| Scientific Background | AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase. It specifically inhibits EGF receptor autophosphorylation and EGF-dependent cell growth. |
| References |
1. Ben-Bassat H., et al. (1999).J. Pharm. Exp. Ther. 290(3): 1442–1457. 2. Kleinberger-Doron N., Shelah N., Capone R., Gazit A., & Levitzki A. (1998) Exp. Cell . Res. 241(2): 340–351. |
Product Images
Chemical structure of AG 494 (SIH-491), a EGF receptor tyrosine kinase inhibitor. CAS #: 133550-35-3. Molecular Formula: C16H12N2O3. Molecular Weight: 280.3 g/mol.
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