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| Product Name | AG 879 |
| Description |
NGFR kinase inhibitor |
| Purity | 99% (TLC) |
| CAS No. | 148741-30-4 |
| Molecular Formula | C18H24N2OS |
| Molecular Weight | 316.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow solid |
| SMILES | CC(C1=CC(C=C(C(C)(C)C)C1=O)=CC(=C(S)N)C#N)(C)C |
| InChI | InChI=1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,22H,20H2,1-6H3/b16-12+ |
| InChIKey | LCUMYVYIHXYBIA-FOWTUZBSSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | AG 879 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-429) |
Biological Description
| Alternative Names | Tyrphostin AG 879, α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide |
| Research Areas | Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors |
| PubChem ID | 5487525 |
| Scientific Background | A879 is a selective inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. It also inhibits ErbB2 and VEGFR-2. |
| References |
1. He H., et al. (2004) Cancer Biol. Therapy. 3(1): 96–101. 2. Ohmichi M., et al. (1993) Biochem. 32(17): 4650–4658. |
Product Images
Chemical structure of AG 879 (SIH-429), a NGFR kinase inhibitor. CAS #: 148741-30-4. Molecular Formula: C18H24N2OS. Molecular Weight: 316.5 g/mol.
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