DMPO

Spin trapping reagent

Catalog No. SIH-324

0 out of 5 based on 0 customer ratings
CAS No. 3317-61-1
Molecular Formula C6H11NO
SKU: SIH-324 Categories: ,

Clear
SIH-324_DMPO_Chemical_Structure.png
Product Name DMPO
Description

Spin trapping reagent

Purity >98%
CAS No. 3317-61-1
Molecular Formula C6H11NO
Molecular Weight 113.16
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Agent, Small Molecules
Solubility Soluble to 100 mM in ethanol and to 100 mM in DMSO
Source Synthetic
Appearance Liquid
SMILES CC1(CCC=[N+]1[O-])C
InChI InChI=1S/C6H11NO/c1-6(2)4-3-5-7(6)8/h5H,3-4H2,1-2H3
InChIKey VCUVETGKTILCLC-UHFFFAOYSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S24/25- Avoid contact with shin and eyes
Cite This Product DMPO (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-324)

Biological Description

Alternative Names 2,2-Dimethyl-3,4-dihydro-2H-pyrrole 1-oxide, 5,5-Dimethyl-1-Pyrroline-N-Oxide, 3,​4-​dihydro-​2,​3-​dimethyl-​2H-​pyrrole 1-​oxide
Research Areas Cancer, Oxidative Stress
PubChem ID 1774
Scientific Background DMPO (5,5-dimethyl-1-pyrroline N-oxide) is a spin trap used to detect reactive oxygen species and free radicals in biological systems. Its low toxicity and favorable pharmacokinetics make it suitable for in vivo studies. DMPO adducts can be formed with protein and DNA radicals, aiding in the investigation of oxidative stress—a key contributor to neurodegenerative diseases. Caution is advised when interpreting results in the presence of nitric oxide due to potential interference.
References 1. Reszka K.J., et al. (2006) Nitric Oxide 15: 133-141.
2. Ramirez D.C., Gomez-Mejiba S.E., and Mason R.P. (2007) Nat Protoc. 2(3): 512-522.
3. Khan N., et al. (2003) Free Radic. Biol. Med 34:1473–1481.
4. Haseloff R.F., et al. (1997) FEBS Lett 418:73–75.
5. Schaefer C.F., Janzen E.G., West M.S., Poyer J.L., and Kosanke S.D. (1996) Free Radic. Biol. Med 21:427–436.
6. Anzai K., et al. (2003) Arch. Biochem. Biophys 415:251–256.
7. Chatterjee S., Ehrenshaft, M., Bhattacharjee ,S., Derterding, L.J., Bonini, M.G., Corbett, J., Kadiiska, M.B., Tomer K.B. and Mason, R.P. 2009 Free Radic. Med. and Biol. 46:454-461.

Product Images

<p>Chemical structure of DMPO (SIH-324), a Nitrone adduct formation. CAS #: 3317-61-1. Molecular Formula: C6H11NO. Molecular Weight: 13.16 g/mol.</p>

Chemical structure of DMPO (SIH-324), a Nitrone adduct formation. CAS #: 3317-61-1. Molecular Formula: C6H11NO. Molecular Weight: 13.16 g/mol.

Reviews

Reviews

There are no reviews yet.

Be the first to review “DMPO”

Your email address will not be published. Required fields are marked *