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| Product Name | Imiquimod |
| Description |
TLR7/8 Agonist |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 99011-02-6 |
| Molecular Formula | C14H16N4 |
| Molecular Weight | 240.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | May be dissolved in DMSO (2 mg/ml, warm) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N |
| InChI | InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17) |
| InChIKey | DOUYETYNHWVLEO-UHFFFAOYSA-N |
| Safety Phrases | Classification: Acute toxicity, Oral (Category 3), H301 Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Hazard statement(s) H301 Toxic if swallowed. H315 Causes skin irritation. H319 Causes serious eye irritation. Precautionary statement(s) P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/ eye protection/ face protection. P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/ doctor. Rinse mouth. P302 + P352 IF ON SKIN: Wash with plenty of water. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 + P364 Take off contaminated clothing and wash it before reuse. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | Imiquimod (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-601) |
Biological Description
| Alternative Names | 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine; R837; S26308; TMX-101 |
| Research Areas | Alzheimer's Disease, Cell Signaling, Immunology, Innate Immunity, Neurodegeneration, Neuroscience, Protein Phosphorylation, Serine / Threonine Kinases, TLR Signaling |
| PubChem ID | 57469 |
| Scientific Background | Imiquimod is an immune response modifier that activates toll-like receptors 7 and 8 (TLR7/8), leading to the production of cytokines such as interferon-α, IL-6, and TNF-α. It also acts as an adenosine A1 and A2A receptor antagonist. While primarily used in dermatology for treating basal cell carcinoma, Imiquimod’s immunomodulatory properties are being explored in neuroinflammation research. Its ability to activate innate immune pathways and modulate adenosine signaling suggests potential applications in neurodegenerative diseases characterized by immune dysregulation and glial activation. |
| References | 1. Kan Y., et al. (2012) J Virol. 86(19): 10338-10346. |
Product Images
Chemical structure of Imiquimod (SIH-601), a TLR7-8 Agonist. CAS #: 99011-02-6. Molecular Formula: C14H16N4. Molecular Weight: 240.3 g/mol.
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