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| Product Name | Quisqualic Acid |
| Description |
Glutamate receptor agonist |
| Purity | 99.2% |
| CAS No. | 52809-07-1 |
| Molecular Formula | C5H7N3O5 |
| Molecular Weight | 189.13 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | Soluble to 100 mM in 1eq. NaOH; 10 mM in water |
| Source | Isolated from Quisqualis fructus |
| Appearance | Off white solid |
| SMILES | [C@H](N)(CN1OC(=O)NC1=O)C(=O)O |
| InChI | InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1 |
| InChIKey | ASNFTDCKZKHJSW-REOHCLBHSA-N |
| Safety Phrases |
Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H302 + H312 Harmful if swallowed or in contact with skin H332 Harmful if inhaled. Precautionary statements: P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ protective clothing. P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P312 Call a POISON CENTER or doctor/ physician if you feel unwell. P322 Specific measures (see supplemental first aid instructions on this label). P330 Rinse mouth. P363 Wash contaminated clothing before reuse. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | Quisqualic Acid (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-418) |
Biological Description
| Alternative Names | (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid |
| Research Areas | AMPA Receptors, Glutamate Receptors, Ion Channels, Neuroscience, Neurotransmitter Receptors |
| PubChem ID | 40539 |
| Scientific Background | Quisqualic acid is a potent agonist of AMPA and metabotropic glutamate receptors, used to induce excitotoxicity in experimental models. In neuroscience, it is employed to study glutamate-mediated neuronal injury, synaptic transmission, and neurodegeneration. Quisqualic acid triggers calcium influx and oxidative stress, mimicking pathological conditions observed in stroke and neurodegenerative diseases. Its application helps elucidate the role of glutamatergic signaling in neuronal survival and the development of excitotoxic damage. Quisqualic acid is instrumental in evaluating neuroprotective agents and understanding excitatory neurotransmission in the brain. |
| References |
1. Schulte M., Roon R., Chalmers D., Sunter D., & Koerner J. (1994) Brain Res. 203-7. 2. Schoepp D., & Conn P. (1993) Trends Pharmacol Sci. 13-20. |
Product Images
Chemical structure of Quisqualic Acid (SIH-418), a Glutamate receptor agonist. CAS #: 52809-07-1. Molecular Formula: C5H7N3O5. Molecular Weight: 189.13 g/mol.
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