Alsterpaullone

CDK, GSK Inhibitor

Catalog No. SIH-431

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CAS No. 237430-03-4
Molecular Formula C16H11N3O3
SKU: SIH-431 Categories: ,

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SIH-431_Alsterpaullone_Chemical_Structure.png
Product Name Alsterpaullone
Description

CDK, GSK Inhibitor

Purity >98% (HPLC)
CAS No. 237430-03-4
Molecular Formula C16H11N3O3
Molecular Weight 293.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO; insoluble in water or 100% ethanol
Source Synthetic
Appearance Yellow to brown powder
SMILES C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)[N+](=O)[O-]
InChI InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
InChIKey OLUKILHGKRVDCT-UHFFFAOYSA-N
Safety Phrases Classification:
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well - ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supplemental first aid instructions on this label).
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well - ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product Alsterpaullone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-431)

Biological Description

Alternative Names 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 5005498
Scientific Background Alsterpaullone is a potent inhibitor of CDK1/cyclin B. It is also a potent and selective inhibitor of GSK-3β and CDK5/p25. Alsterpaullone induces apoptosis by activating caspase-8 and caspase-9, followed by disruption of the mitochondrial potential. It is cell-permeable.
References 1. Zaharevitz D.W., et al. (1999). Cancer Research. 59(11): 2566–2569.
2. Lahusen T., De Siervi A., Kunick C., & Senderowicz A.M. (2003) Mol. Carcinogenesis. 36(4): 183–194.
3. Schultz C., et al. (1999) J. Med. Chem. 42(15): 2909–2919.

Product Images

<p>Chemical structure of Alsterpaullone (SIH-431), a GSK3beta kinase inhibitor,  CDK5/p25 inhibitor. CAS #: 237430-03-4. Molecular Formula: C16H11N3O3. Molecular Weight: 293.3 g/mol.</p>

Chemical structure of Alsterpaullone (SIH-431), a GSK3beta kinase inhibitor, CDK5/p25 inhibitor. CAS #: 237430-03-4. Molecular Formula: C16H11N3O3. Molecular Weight: 293.3 g/mol.

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