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| Product Name | AM 580 |
| Description |
Rar agonist |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 102121-60-8 |
| Molecular Formula | C22H25NO3 |
| Molecular Weight | 351.4 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Agonist |
| Solubility | May be dissolved in DMSO (35 mg/ml); or Ethanol (18 mg/ml) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C |
| InChI | InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26) |
| InChIKey | SZWKGOZKRMMLAJ-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | AM 580 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-600) |
Biological Description
| Alternative Names | 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid; CD336; NSC 608001; Ro 40-6055 |
| Research Areas | Cancer, Cell Signaling, Epigenetics and Nuclear Signaling, Neuroscience, Oxidative Stress, Transcription |
| PubChem ID | 2126 |
| Scientific Background | AM 580 is a selective agonist of the retinoic acid receptor alpha (RARα), structurally related to retinoic acid. It modulates immune responses by promoting Th2 cytokine production and suppressing Th1 cytokines. In neurodegenerative disease research, AM 580 has been shown to inhibit microglial activation and reduce neuroinflammation, particularly in Alzheimer’s disease models. Its ability to influence retinoid signaling pathways and immune modulation makes it a promising candidate for therapeutic development in neuroinflammatory and neurodegenerative conditions. |
| References | 1. Wang O., Thome R., Rostami A., Ma C-G., Zhang G-X. (2019) Nature. 16: 727-729. 2. Bosch A., et al. (2012) Breast Cancer Res. 14(4): R121. |
Product Images
Chemical structure of AM 580 (SIH-600), a RAR Agonist. CAS #: 102121-60-8. Molecular Formula: C22H25NO3. Molecular Weight: 351.4 g/mol.
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