AM 580

Name: AM 580
SKU: SIH-600
Availability: InStock

Rar agonist

Catalog No. SIH-600

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CAS No.	102121-60-8
Molecular Formula	C22H25NO3

SKU: SIH-600 Categories: Agonist, Small Molecules

Product Name	AM 580
Description	Rar agonist
Purity	>98% (HPLC); NMR (conforms)
CAS No.	102121-60-8
Molecular Formula	C₂₂H₂₅NO₃
Molecular Weight	351.4
Field of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Storage Temperature	-20ºC
Shipping Temperature	Shipped Ambient
Product Type	Agonist
Solubility	May be dissolved in DMSO (35 mg/ml); or Ethanol (18 mg/ml)
Source	Synthetic
Appearance	Off-white powder
SMILES	CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C
InChI	InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
InChIKey	SZWKGOZKRMMLAJ-UHFFFAOYSA-N
Safety Phrases	Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Cite This Product	AM 580 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-600)

Alternative Names	4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid; CD336; NSC 608001; Ro 40-6055
Research Areas	Cancer, Cell Signaling, Epigenetics and Nuclear Signaling, Neuroscience, Oxidative Stress, Transcription
PubChem ID	2126
Scientific Background	AM-580, a benzoic derivative of retinoic acid and a selective RAR-α agonist, has been shown to significantly reduce the production of Th1 cytokines but promote Th2 cytokines in human PBMCs7 and to inhibit microglial activation, thus acting beneficially in Alzheimer's disease treatment. It also is known to inhibit tumor cell proliferation and induces apoptosis.
References	1. Wang O., Thome R., Rostami A., Ma C-G., Zhang G-X. (2019) Nature. 16: 727-729. 2. Bosch A., et al. (2012) Breast Cancer Res. 14(4): R121.

Chemical structure of AM 580 (SIH-600), a RAR Agonist. CAS #: 102121-60-8. Molecular Formula: C22H25NO3. Molecular Weight: 351.4 g/mol.

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