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| Product Name | Amlodipine |
| Description |
L-type Ca channel blocker |
| Purity | >98% |
| CAS No. | 111470-99-6 |
| Molecular Formula | C20H25ClN2O5•C6H5SO3H |
| Molecular Weight | 567.05 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in water |
| Source | Synthetic |
| Appearance | White Solid |
| SMILES | CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN |
| InChI | InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11 |
| InChIKey | HTIQEAQVCYTUBX-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection Risk Phrases: R22 - Harmful if swallowed R62 - Possible risk of impaired fertility Hazard Phrases: H302-H315-H319-H335 Precautionary Phrases: P261-P305 + P351 + P338 |
| Cite This Product | Amlodipine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-315) |
Biological Description
| Alternative Names | 3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate, Norvasc |
| Research Areas | Calcium Channels, Ion Channels, Neuroscience, Voltage-Gated Calcium Channels |
| PubChem ID | 2162 |
| Scientific Background | Amlodipine is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. It acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and hence reducing blood pressure. |
| References |
1. Luksa J., Josic D., Kremser M., Kopitar Z and Milutinovic S. (1997) J Chromatorgraphy. B, Biomed Sci and App. 693(2): 367-375. 2. Bahl V.K., Jadhav U.M., Thacker H.P. (2009) Am J Cardiovasc Drugs. 9(3): 135-142. |
Product Images
Chemical structure of Amlodipine (SIH-315), a L-type Ca channel blocker. CAS #: 111470-99-6. Molecular Formula: C20H25ClN2O5 · C6H5SO3H . Molecular Weight: 567.05 g/mol.
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