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| Product Name | Anle138b |
| Description |
Synuclein aggregation inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 882697-00-9 |
| Molecular Formula | C16H11BrN2O2 |
| Molecular Weight | 343.2 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (15 mg/ml, warm) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | BrC1=CC(C2=CC(C3=CC(OCO4)=C4C=C3)=NN2)=CC=C1 |
| InChI | 1S/C16H11BrN2O2/c17-12-3-1-2-10(6-12)13-8-14(19-18-13)11-4-5-15-16(7-11)21-9-20-15/h1-8H,9H2,(H,18,19) |
| InChIKey | RCQIIBJSUWYYFU-UHFFFAOYSA-N |
| Safety Phrases |
Classification: Warning. Hazard Statements H315 - H319 - H335 Precautionary Statements P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338 |
| Cite This Product | Anle138b (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-607) |
Biological Description
| Alternative Names | 3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole, 5-(1,3-Benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole, Anle 138b, CID 44608289 |
| Research Areas | Neurodegeneration, Neuroscience, Parkinson's Disease, Synuclein |
| PubChem ID | 44608289 |
| Scientific Background | Anle138b is an oligomeric aggregation inhibitor that inhibits the formation of pathological prion protein (PrPSc) and α-synuclein aggregates in vitro. Anle138b prevents accumulation of PrPSc in the brain and the spleen. Anle138b exhibits neuroprotective effects in a Parkinson's disease mouse model and improves motor performance in an α-synucleinopathy model. |
| References | 1. Wagner J. et al. (2013) Acta Neuropathol. 125 (6): 795-813. |
Product Images
Chemical structure of Anle138b (SIH-607), a Synuclein aggregation inhibitor. CAS #: 882697-00-9. Molecular Formula: C16H11BrN2O2. Molecular Weight: 343.2 g/mol.
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