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| Product Name | D-LAP5.Na |
| Description |
NMDA receptor antagonist |
| Purity | >99.0 |
| CAS No. | 1303993-72-7 |
| Molecular Formula | C5H12NO5P•Na |
| Molecular Weight | 219.11 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Antagonist |
| Solubility | Soluble to 100 mM in water |
| Source | Synthetic |
| Appearance | White solid |
| SMILES | C([P](O)(O)=O)CCC(C(O)=O)N |
| Safety Phrases |
Classification: Not WHMIS controlled. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | D-LAP5.Na (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-414) |
Biological Description
| Alternative Names | DL-amino-5-phosphonopentaoic acid sodium salt |
| Research Areas | Glutamate Receptors, Ion Channels, Neuroscience, Neurotransmitter Receptors, NMDA Receptors |
| Scientific Background | D-LAP5.Na is the sodium salt form of D-2-Amino-5-phosphonopentanoic acid, a selective NMDA receptor antagonist. It inhibits glutamate-induced excitotoxicity by blocking NMDA receptor activation, a process implicated in the pathogenesis of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. The sodium salt enhances solubility and bioavailability, making it suitable for in vivo studies. D-LAP5.Na is used to study synaptic plasticity, neuroprotection, and the molecular basis of cognitive decline. |
| References |
1. Davies J., & Watkins J. (1982) Brain Res. 378-86. 2. Schulte M., Roon R., Chalmers D., Sunter D., & Koerner J. (1994) Brain Res. 203-7. |
Product Images
Chemical structure of D-LAP5.Na (SIH-414), a Glutamate-NMDA receptor antagonist. CAS #: 1303993-72-7. Molecular Formula: C5H12NO5P.Na. Molecular Weight: 219.11 g/mol.
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