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| Product Name | FPS-ZM1 |
| Description |
RAGE antagonist |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 945714-67-0 |
| Molecular Formula | C20H22ClNO |
| Molecular Weight | 327.1 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Antagonist |
| Solubility | May be dissolved in DMSO (30 mg/ml); or Ethanol (25 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | C1CCC(CC1)N(CC2=CC=CC=C2)C(=O)C3=CC=C(C=C3)Cl |
| InChI | InChI=1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2 |
| InChIKey | XDFKWGIBQMHSOH-UHFFFAOYSA-N |
| Safety Phrases |
This product does not require a Material Safety Data Sheet under the Occupational Safety and Health Administration standard entitled "Hazard Communication" 29 CFR 1910.1200 for the United States. The product does not meet the criteria of W.H.M.I.S. classification as a controlled product. As a result, a W.H.M.I.S. Material Safety Data Sheet is not required (in Canada) for this product. |
| Cite This Product | FPS-ZM1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-561) |
Biological Description
| Alternative Names | 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide, FPS-ZM1; N-benzyl-4-chloro-N-cyclohexylbenzamide; 945714-67-0; FPS ZM1; SCHEMBL1169839; EX-A924 |
| Research Areas | Alzheimer's Disease, Neurodegeneration, Neuroscience, Parkinson's Disease |
| PubChem ID | 24752728 |
| Scientific Background | FPS-ZM1 is a high-affinity inhibitor of the receptor for advanced glycation end-products (RAGE), which is implicated in neuroinflammation and amyloid-beta transport across the blood-brain barrier. In neurodegenerative disease research, FPS-ZM1 has demonstrated efficacy in reducing amyloid-beta accumulation, oxidative stress, and inflammatory signaling in models of Alzheimer’s disease. Its ability to cross the blood-brain barrier and selectively block RAGE makes it a promising therapeutic candidate for mitigating neurodegeneration and cognitive decline. |
Product Images
Chemical structure of FPS-ZM1 (SIH-561), a RAGE antagonist. CAS #: 945714-67-0. Molecular Formula: C20H22ClNO. Molecular Weight: 327.1 g/mol.
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