Naloxone HCl

Opioid Receptor Antagonist

Catalog No. SIH-620

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CAS No. 357-08-4
Molecular Formula C19H21NO4 • HCl
SKU: SIH-620 Categories: ,

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SIH-620-Naloxone-HCl-Chemical-Structure
Product Name Naloxone HCl
Description

Opioid Receptor Antagonist

Purity >98% (HPLC); NMR (conforms)
CAS No. 357-08-4
Molecular Formula C19H21NO4 • HCl
Molecular Weight 363.8
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Antagonist
Solubility May be dissolved in DMSO (35 mg/ml); water (30 mg/ml)
Source Synthetic
Appearance White crystalline powder
SMILES C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl
InChI InChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1
InChIKey RGPDIGOSVORSAK-STHHAXOLSA-N
Safety Phrases Classification: Warning.

Hazard Statements: H302
Precautionary Statements: P264 - P270 - P301 + P312 - P501
Cite This Product Naloxone HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-620)

Biological Description

Alternative Names 5α)-4,5-Epoxy-3,14-dihydro-17-(2-propenyl)morphinan-6-one, hydrochloride
PubChem ID 5464092
Scientific Background Naloxone HCl is a pan-opioid receptor antagonist widely used in clinical settings for opioid overdose reversal. Beyond its emergency applications, Naloxone is being explored in neuroscience for its ability to modulate opioid receptor-mediated signaling. It has been studied in models of pruritus, wound healing, and neuroimmune interactions, offering insights into the role of opioid receptors in neuroinflammation and neurodegenerative disease mechanisms.
References 1. Le Bourdonnec B.,et al. (2008)Bioorg. Med. Chem. Lett. 18:2006.
2. EW., Boyer (2012) New Engl. J. Med. 367:146.
3. WangY., et al. (2017) Transl. Res. 185:13.
4. Wright FL., and RJ Rodgers (2013) Psychopharmacology (Berl.) 226:415.

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