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| Product Name | Z-Guggulsterone |
| Description |
FXR Antagonist |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 39025-23-5 |
| Molecular Formula | C21H28O2 |
| Molecular Weight | 312.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Antagonist |
| Solubility | May be dissolved in DMSO (6 mg/ml, warm); or Ethanol (3 mg/ml, warm) |
| Source | Synthetic |
| Appearance | Off-white powder |
| SMILES | CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C |
| InChI | InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1 |
| InChIKey | WDXRGPWQVHZTQJ-OSJVMJFVSA-N |
| Safety Phrases |
Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Cite This Product | Z-Guggulsterone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-591) |
Biological Description
| Alternative Names | (Z)-Pregna-4,17(20)-diene-3,16-dione |
| Research Areas | Apoptosis, Cancer |
| PubChem ID | 6450278 |
| Scientific Background | Z-Guggulsterone is a bioactive phytosteroid that functions as a selective antagonist of the farnesoid X receptor (FXR), inhibiting FXR transactivation and modulating bile acid signaling. It also acts as an inhibitor of the retinoic acid receptor (RAR) pathway. In neuroscience, Z-Guggulsterone has shown potential in attenuating astrocyte-mediated neuroinflammation by suppressing the toll-like receptor 4 (TLR4) pathway. This anti-inflammatory activity positions it as a candidate for further investigation in neurodegenerative disease models where glial activation and chronic inflammation are key pathological features. |
Product Images
Chemical structure of Z-Guggulsterone (SIH-591), a FXR Antagonist. CAS #: 39025-23-5. Molecular Formula: C21H28O2. Molecular Weight: 312.5 g/mol.
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