Edaravone

Free radical scavenger

Catalog No. SIH-152

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CAS No. 89-25-8
Molecular Formula C10H10N2O
SKU: SIH-152 Categories: ,

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SIH-152_Edaravone_Chemical_Structure.png
Product Name Edaravone
Description

Free radical scavenger

Purity >98%
CAS No. 89-25-8
Molecular Formula C10H10N2O
Molecular Weight 174.2
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Antioxidant
Solubility Soluble to 100 mM in DMSO
Source Synthetic
Appearance Light Yellow Solid
SMILES CC1=NN(C(=O)C1)C2=CC=CC=C2
InChI InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
InChIKey QELUYTUMUWHWMC-UHFFFAOYSA-N
Safety Phrases Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R62 - Possible risk of impaired fertility
R68 - Possible risk of irreversible effects
Hazard Phrases:
H302-H315-H319-H335

Precautionary Phrases: P261-P305 + P351 + P338
Cite This Product Edaravone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-152)

Biological Description

Alternative Names 5-Methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, MCI-186
Research Areas Cancer, Oxidative Stress
PubChem ID 4021
Scientific Background Edaravone is a free radical scavenger and antioxidant that has demonstrated neuroprotective effects in models of ischemic stroke and neurodegeneration. It mitigates oxidative stress by inhibiting lipid peroxidation and the lipoxygenase pathway, thereby preserving neuronal integrity. Edaravone has been shown to protect dopaminergic neurons from MPTP-induced neurotoxicity, a model of Parkinson’s disease. Its ability to cross the blood-brain barrier and reduce reactive oxygen species makes it a valuable agent in the treatment of neurodegenerative conditions characterized by oxidative damage and mitochondrial dysfunction.
References 1. Kawai G., et al. (1997) J Pharmacol Exp Ther. 281(2): 921-927.
2. Yuki S., and Koqure K. (1997) Mol Chem Neuropathol. 32(1-3): 123-128.

Product Images

<p>Chemical structure of Edaravone (SIH-152), a Free radical scavenger. CAS #: 89-25-8. Molecular Formula: C10H10N2O. Molecular Weight: 174.2 g/mol.</p>

Chemical structure of Edaravone (SIH-152), a Free radical scavenger. CAS #: 89-25-8. Molecular Formula: C10H10N2O. Molecular Weight: 174.2 g/mol.

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