Discovery through Partnership | Excellence through Quality
| Product Name | Aphidicolin |
| Description |
DNA polymerase inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 38966-21-1 |
| Molecular Formula | C20H34O4 |
| Molecular Weight | 338.5 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (10 mg/ml); or ethanol (1 mg/ml) |
| Source | Synthetic |
| Appearance | White powder |
| SMILES | C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O |
| InChI | InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1 |
| InChIKey | NOFOAYPPHIUXJR-APNQCZIXSA-N |
| Safety Phrases |
Classification: Caution: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection |
| Cite This Product | Aphidicolin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-605) |
Biological Description
| Alternative Names | (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol; (from Nigrospora sp.) |
| Research Areas | Cell Signaling, Epigenetics and Nuclear Signaling, Neuroscience |
| PubChem ID | 457964 |
| Scientific Background | Aphidicolin specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases (1). Arrests cell cycle at early S phase while allowing continued cell growth(2). Potentiates apoptosis induction induced by other agents(3). Increases gene amplification frequency in HeLa S3 cells overexpressing Bcl-2(4). |
| References |
1.,Syvaoja J., et al. (1990) Proc. Natl. Acad. Sci. USA. 87(17):6664-6668. 2.,Urbani L., et al. (1995) Exp. Cell Res. 219(1):159-168. 3.,Kuwakado K., et al. (1993) Biochem. Pharmacol. 46:1909-1916. 4.,Yin D.X., and Schimke R.T. (1996) Proc. Natl. Acad. Sci. USA. 93:3394-3398. |
Product Images
Chemical structure of Aphidicolin (SIH-605), a DNA polymerase inhibitor. CAS #: 38966-21-1. Molecular Formula: C20H34O4. Molecular Weight: 338.5 g/mol.
Powered by Bioz
Reviews
There are no reviews yet.