AR A014418

GSK-3 kinase inhibitor

Catalog No. SIH-492

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CAS No. 487021-52-3
Molecular Formula C12H12N4O4S
SKU: SIH-492 Categories: ,

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SIH-492_AR-A_014418_Chemical_Structure.png
Product Name AR A014418
Description

GSK-3 kinase inhibitor

Purity >95% (HPLC)
CAS No. 487021-52-3
Molecular Formula C12H12N4O4S
Molecular Weight 308.3
Field of Use Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Properties

Storage Temperature -20ºC
Shipping Temperature Shipped Ambient
Product Type Inhibitor
Solubility Soluble in DMSO, methanol, 100% ethanol or ethyl acetate
Source Synthetic
Appearance White to off-white solid
SMILES COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]
InChI InChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
InChIKey YAEMHJKFIIIULI-UHFFFAOYSA-N
Safety Phrases Classification:
Acute toxicity, Oral (Category 4), H302
Skin irritation (Category 2), H315
Serious eye damage (Category 1), H318
Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335

Safety Phrases:
S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:
H302 Harmful if swallowed.
H315 Causes skin irritation.
H318 Causes serious eye damage.
H335 May cause respiratory irritation.

Precautionary statements:
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310 Immediately call a POISON CENTER or doctor/ physician.
P321 Specific treatment (see supplemental first aid instructions on this label).
P330 Rinse mouth.
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.
Cite This Product AR A014418 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-492)

Biological Description

Alternative Names N-(4-Methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea
Research Areas Apoptosis, Cancer, Cancer Growth Inhibitors, Cell Signaling, Tyrosine Kinase Inhibitors
PubChem ID 448014
Scientific Background AR A014418 is a highly selective glycogen synthase kinase 3 (GSK-3) inhibitor. GSK-3 is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer′s disease. AR A014418 is cell permeable.
References 1. Bhat R.V., & Budd S.L. (2002) Neuro-Signals. 11(5): 251–261.
2. Gould T.D., Einat H., Bhat R., & Manji H.K. (2004) Int. J. Neuropsychopharmacology (CINP). 7(4): 387–390.

Product Images

<p>Chemical structure of AR A014418 (SIH-492), a GSK-3 kinase inhibitor. CAS #: 487021-52-3. Molecular Formula: C12H12N4O4S. Molecular Weight: 308.3 g/mol.</p>

Chemical structure of AR A014418 (SIH-492), a GSK-3 kinase inhibitor. CAS #: 487021-52-3. Molecular Formula: C12H12N4O4S. Molecular Weight: 308.3 g/mol.

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