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| Product Name | AS-8351 |
| Description |
KDM5B histone demethylase inhibitor |
| Purity | >98% (TLC); NMR (Conforms) |
| CAS No. | 796-42-9 |
| Molecular Formula | C17H13N3O2 |
| Molecular Weight | 291.3 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (45 mg/ml); or ethanol (10 mg/ml, warm); or DMF (30 mg/ml) |
| Source | Synthetic |
| Appearance | Yellow powder |
| SMILES | O=C(NNC=C1/C(=O)C=Cc2ccccc12)c3ccncc3 |
| InChI | InChI=1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,19H,(H,20,22)/b15-11- |
| InChIKey | UBECDIQQXGETMR-PTNGSMBKSA-N |
| Safety Phrases |
GHS Classification: Skin irritation (Category 2), H315 Eye irritation (Category 2A), H319 Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335 Signal word: Warning Hazard statement(s): H315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s): P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/doctor if you feel unwell. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P332 + P313 If skin irritation occurs: Get medical advice/ attention. P337 + P313 If eye irritation persists: Get medical advice/ attention. P362 Take off contaminated clothing and wash before reuse. P403 + P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. P501 Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | AS-8351 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-558) |
Biological Description
| Alternative Names | AS8351, 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone; NSC-51355, N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide, N'-[(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide, N'-[(Z)-(2-oxo-1-naphthylidene)methyl]pyridine-4-carbohydrazide, N'-[(2-oxo-1-naphthylidene)methyl]pyridine-4-carbohydrazide, N'-[(Z)-(2-oxo-1-naphthylidene)methyl]-4-pyridinecarbohydrazide, N'-[(2-oxo-1-naphthylidene)methyl]-4-pyridinecarbohydrazide, N'-[(Z)-(2-keto-1-naphthylidene)methyl]isonicotinohydrazide, N'-[(2-keto-1-naphthylidene)methyl]isonicotinohydrazide, 796-42-9, 2-Hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone, NSC51355, NCI60_004242, ZINC00061171, CBDivE_006818, 311 Iron Chelator, 2-Hydroxy-1-naphthaldehyde isonicotinoyl hydrazone |
| Research Areas | Stem Cells |
| PubChem ID | 5353827 |
Product Images
Chemical structure of AS-8351 (SIH-558), a KDM5B histone demethylase inhibitor. CAS #: 796-42-9. Molecular Formula: C17H13N3O2. Molecular Weight: 291.3 g/mol.
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