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| Product Name | Bafilomycin A1 |
| Description |
Autophagy inhibitor |
| Purity | >98% (HPLC); NMR (conforms) |
| CAS No. | 88899-55-2 |
| Molecular Formula | C35H58O9 |
| Molecular Weight | 622.84 |
| Field of Use | Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only. |
Properties
| Storage Temperature | -20ºC |
| Shipping Temperature | Shipped Ambient |
| Product Type | Inhibitor |
| Solubility | May be dissolved in DMSO (50mg/mL) |
| Source | Synthetic |
| Appearance | White powder to colorless film. |
| SMILES | [C@]1(O[C@@H]([C@H]([C@H](O)C1)C)C(C)C)(O)[C@H]([C@H](O)[C@@H]([C@H]2OC(=O)C(=C/C(=C/[C@H]([C@@H](O)[C@H](CC(=C/C=C/[C@@H]2OC) |
| InChI | InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H |
| InChIKey | XDHNQDDQEHDUTM-JQWOJBOSSA-N |
| Safety Phrases |
Classification: D2B- Toxic Material Causing Other Toxic Effects Irritant Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315- Causes skin irritation. H319- Causes serious eye irritation. H335- May cause respiratory irritation. Precautionary statements: P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P264- Wash skin thoroughly after handling. P271- Use only outdoors or in a well-ventilated area. P280- Wear protective gloves/ eye protection/ face protection. P302 + P352- IF ON SKIN: Wash with plenty of soap and water. P304 + P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312- Call a POISON CENTER or doctor/ physician if you feel unwell. P321- Specific treatment (see supplemental first aid instructions on this label). P332 + P313- If skin irritation occurs: Get medical advice/ attention. P337 + P313- If eye irritation persists: Get medical advice/ attention. P362- Take off contaminated clothing and wash before reuse. P403 + P233- Store in a well-ventilated place. Keep container tightly closed. P405- Store locked up. P501- Dispose of contents/ container to an approved waste disposal plant. |
| Cite This Product | Bafilomycin A1 (StressMarq Biosciences, Canada, Cat # SIH-391) |
Biological Description
| Alternative Names | (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one |
| Research Areas | Autophagy, Cancer |
| PubChem ID | 6436223 |
| Scientific Background | Bafilomycin A1 is a macrolide antibiotic that selectively inhibits vacuolar-type H⁺-ATPases (V-ATPases), disrupting lysosomal acidification and autophagic flux. In neuroscience, Bafilomycin A1 is widely used to study autophagy, a critical process for neuronal health and protein clearance. By blocking autophagosome-lysosome fusion or lysosomal degradation, Bafilomycin A1 allows researchers to assess autophagic activity and flux in neuronal cells. Impaired autophagy is a common feature in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS. Bafilomycin A1 is instrumental in elucidating the role of lysosomal dysfunction in these conditions and in evaluating therapeutic strategies aimed at restoring autophagic balance. |
| References |
1. Gagliardi S., et al. (1999). Curr Med Chem. 6(12): 1197-212. 2. Fass E., et al. (2006). J Biol Chem. 281(47): 36303-16. 3. Yamamoto A., et al. (1998). Cell Struct Funct. 23(1): 33-42. |
Product Images
Chemical structure of Bafilomycin A1 (SIH-391), a Autophagy inhibitor. CAS #: 88899-55-2. Molecular Formula: C35H58O9. Molecular Weight: 622.84 g/mol.
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StressMarq Biosciences :
Based on validation through cited publications.
Eric Wang :
We ordered this inhibitor and utilized 100 nm to pre-treat differentiated THP-1 cells for 1 h before incubating with autophagy inducer. We showed that this inhibitor can efficiently inhibit the autophagy flux by measuring the level of LC3-II. We recommend it.